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Karen Tenkhoff began her film career in post-production, working at LucasFilm and the Saul Zaentz Film Company as an assistant editor. She then transitioned into development, working with screenwriters on several projects, including Donnie Brasco (adapted by Paul Attanasio and directed by Mike Newell).
She is currently a producing partner at Wildwood Enterprises, Robert Redford's production company. She has developed a number of film projects for the company, including The Horse Whisperer and The Legend Of Bagger Vance (both directed by Robert Redford), and Pieter Jan Brugge's The Clearing.