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Vytorin
Generic Name:
ezetimibe and simvastatin (ez ET i mibe and SIM va stat in)
Brand Names:
Vytorin
What is Vytorin?
Vytorin contains a combination ezetimibe and simvastatin. Ezetimibe reduces the amount of cholesterol absorbed by the body. Simvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Vytorin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Vytorin is used to treat high cholesterol in adults and children who are at least 10 years old. Vytorin may also be used for other purposes not listed in this medication guide.
Before taking Vytorin
You should not take Vytorin if you are allergic to ezetimibe or simvastatin, if you are pregnant or breast-feeding, or if you have liver disease. If you have any of these other conditions, your doctor may need to adjust your Vytorin dose or order special tests: history of liver disease; history of kidney disease; diabetes; a thyroid disorder; or if you drink more than 2 alcoholic beverages daily. In rare cases, Vytorin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid). You may also be more likely to develop this condition if you are of Chinese descent and you take high-dose Vytorin while also taking medication that contains niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others). Tell your doctor about all other medications you use. Certain other drugs can increase your risk of serious muscle problems, and it is very important that your doctor knows if you are using any of them: amiodarone (Cordarone, Pacerone); danazol (Danocrine); nefazodone (an antidepressant); gemfibrozil (Lopid), fenofibric acid (Fibricor, Trilipix), or fenofibrate (Antara, Fenoglide, Lipofen, Lofibra, Tricor, Triglide); antibiotics such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), or telithromycin (Ketek); antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox), or ketoconazole (Extina, Ketozole, Nizoral, Xolegal); heart or blood pressure medication such as diltiazem (Cartia, Cardizem) or verapamil (Calan, Covera, Isoptin, Verelan); HIV medications such as atazanavir (Reyataz), ritonavir (Norvir), lopinavir/ritonavir (Kaletra), saquinavir (Invirase), and others; medicines that contain niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others); or drugs that weaken your immune system, such as steroids, cancer medicine, or medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf). FDA pregnancy category X. Vytorin can harm an unborn baby or cause birth defects. Do not take Vytorin if you are pregnant. Stop taking this medication and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking Vytorin. Ezetimibe and simvastatin may pass into breast milk and could harm a nursing baby. Do not breast-feed while you are taking Vytorin.
How should I take Vytorin?
Take Vytorin exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Vytorin is usually taken once daily in the evening, with or without food. Your doctor may occasionally change your dose to make sure you get the best results. You may need to stop using Vytorin for a short time if you have surgery or a medical emergency. To be sure Vytorin is helping your condition and is not causing harmful effects, your blood will need to be tested often. Your liver function may also need to be tested. Visit your doctor regularly. Vytorin is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. You may need to take Vytorin on a long-term basis for the treatment of high cholesterol. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Vytorin side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Vytorin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking Vytorin and call your doctor at once if you have any of these serious side effects: unexplained muscle pain, tenderness, or weakness; fever, unusual tiredness, and dark colored urine; swelling, weight gain, urinating less than usual or not at all; or nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Less serious Vytorin side effects may include: headache, memory problems; mild muscle pain; joint pain; numbness or tingly feeling; diarrhea; dizziness, depressed mood; sleep problems (insomnia); or cold symptoms such as stuffy nose, sneezing, sore throat. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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