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Avandamet



Generic Name:

metformin and rosiglitazone (met FOR min and ROE zi GLI ta zone)

Brand Names:

Avandamet

What is Avandamet?

Avandamet is a combination of two oral diabetes medicines that help control blood sugar levels. Avandamet works by decreasing the amount of sugar that the liver produces and the intestines absorb. It also helps to make your body more sensitive to the insulin that you naturally produce. Avandamet is for people with type 2 diabetes who do not use daily insulin injections. This medication is not for treating type 1 diabetes. Avandamet may also be used for other purposes not listed here.

Before taking Avandamet

Do not use Avandamet if you have severe heart failure, kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking Avandamet. Be sure the surgeon knows ahead of time that you are using this medication. Metformin may cause lactic acidosis (the build up of lactic acid in the body) that can start slowly and gradually get worse. Symptoms include muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. Get emergency medical help if you have any of these symptoms of lactic acidosis, even if they are only mild. Early signs of lactic acidosis generally get worse over time and this condition can be fatal. You may be more likely to develop lactic acidosis if you have liver disease, kidney disease, congestive heart failure, a serious infection, if you are dehydrated, or if you drink large amounts of alcohol. Talk with your doctor about your individual risk. Before taking Avandamet, tell your doctor if you have congestive heart failure or heart disease, a history of heart attack or stroke, liver disease, or eye problems caused by diabetes. Some women using Avandamet have started having menstrual periods, even after not having a period for a long time due to a medical condition. You may be able to get pregnant if your periods restart. Talk with your doctor about the need for birth control. Women may also be more likely than men to have bone fractures in the upper arm, hand, or foot while taking Avandamet. Talk with your doctor if you are concerned about this possibility. FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby. Before you take Avandamet, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether metformin and rosiglitazone passes into breast milk or if it could harm a nursing baby. Do not take Avandamet without first talking to your doctor if you are breast-feeding a baby.

Avandamet side effects

Stop using Avandamet and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects: chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; sudden numbness, weakness, headache, confusion, or problems with vision, speech, or balance; feeling short of breath, swelling or rapid weight gain; fever, chills, body aches, flu symptoms; severe blistering, peeling, and red skin rash; or nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Less serious Avandamet side effects may include: sneezing, runny nose, cough or other signs of a cold; back pain, joint or muscle pain; or mild diarrhea. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

































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